.clinical-tools{padding-bottom:30px}.tool-nav{display:grid;grid-template-columns:repeat(3,1fr);gap:12px;margin:0 0 28px}.tool-nav a{padding:18px 20px;border:1px solid var(--line);border-radius:8px;transition:background .2s}.tool-nav a[aria-current]{background:var(--ink);color:white;border-color:var(--ink)}.tool-nav strong,.tool-nav span{display:block}.tool-nav strong{font-size:17px}.tool-nav span{font-size:14px;opacity:.8;margin-top:4px}.tool-panel{border:1px solid var(--line);border-radius:14px;overflow:hidden;background:#fff;box-shadow:0 12px 40px #07335a08}.tool-panel-heading{padding:30px 36px;background:#eef6f7;border-bottom:1px solid var(--line)}.tool-panel-heading .eyebrow{margin-bottom:10px}.tool-panel-heading h2{font-size:32px}.tool-panel-heading p{margin-top:12px;max-width:850px}.tool-layout{display:grid;grid-template-columns: minmax(280px,.85fr) minmax(0,1.4fr)}.tool-inputs{padding:30px;border-right:1px solid var(--line)}.input-grid{display:grid;grid-template-columns:1fr 1fr;gap:18px}.input-grid label{font-size:14px;line-height:1.5;color:var(--ink)}.input-grid label:has(select){grid-column:1/-1}.input-grid input:not([type=checkbox]),.input-grid select{display:block;width:100%;min-width:0;border:1px solid #b9cbd4;background:#fff;border-radius:5px;padding:12px;margin-top:7px;font-size:16px;color:var(--ink)}.input-grid .check-field{grid-column:1/-1;display:flex;align-items:start;gap:9px}.check-field input{margin-top:5px}.tool-inputs .buttons{gap:10px}.tool-result{padding:32px;min-width:0}.result-empty{min-height:260px;display:flex;align-items:center;justify-content:center;text-align:center;color:var(--muted);border:1px dashed #c5d7df;border-radius:8px;padding:25px;background:#fafcfd}.stat-grid{display:grid;grid-template-columns:1fr 1fr;gap:20px}.tool-stat{padding:0 0 24px}.tool-stat strong{font:600 clamp(30px,3vw,48px)/1.15 Manrope;letter-spacing:-.04em;display:block;color:var(--teal)}.tool-stat span{display:block;font-size:14px;color:var(--muted);margin-top:9px}.tool-result h3{font-size:23px;margin:12px 0}.tool-result p{margin:12px 0;font-size:15px;line-height:1.65}.tool-method{padding:24px 32px;background:#f5f8fa;border-top:1px solid var(--line);font-size:14px;color:var(--muted)}.tool-method a,.tool-result p a{color:var(--teal);text-decoration:underline}.milestone-list{margin:15px 0 20px}.milestone-list>div{display:flex;justify-content:space-between;padding:11px 0;border-bottom:1px solid var(--line);gap:16px}.milestone-list strong{color:var(--teal)}.clinical-note{padding:16px;background:#eef5f8;border-left:3px solid #258b98;border-radius:0 6px 6px 0;margin:20px 0;font-size:14px;line-height:1.7}.bmi-ruler{position:relative;height:18px;background:linear-gradient(90deg,#b5d6e3 0 10%,#7fb9cb 10% 28.57%,#5d9fae 28.57% 42.86%,#427e9d 42.86% 57.14%,#286584 57.14% 71.43%,#07335a 71.43%);border-radius:12px;margin-top:25px}.bmi-ruler i{position:absolute;top:-7px;height:32px;border-left:3px solid #00243d;box-shadow:0 0 0 2px white}.ruler-labels{display:flex;justify-content:space-between;font-size:12px!important}.measure-row{margin:20px 0}.measure-row>div:first-child{display:flex;justify-content:space-between;gap:20px;font-size:14px}.measure-track{height:14px;background:#eef3f6;border-radius:10px;margin-top:9px;overflow:hidden}.measure-track span{display:block;height:100%;background:var(--teal);border-radius:10px}.half-chart{display:block;width:100%;margin:20px 0;overflow:visible}.half-chart text{font:13px 'DM Sans',sans-serif;fill:#586778}.print-brand{font-size:12px!important;margin-top:18px!important}.pipeline-summary{display:flex;gap:25px;flex-wrap:wrap;align-items:center;padding:20px 0;border-top:1px solid var(--line);margin-bottom:22px}.pipeline-summary strong{font-size:25px;color:var(--teal)}.pipeline-summary span{font-size:14px}.pipeline-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:22px;margin-bottom:30px}.pipeline-card{border:1px solid var(--line);border-radius:12px;padding:28px;box-shadow:0 5px 20px #07335a05;transition:transform .2s,box-shadow .2s}.pipeline-card:hover{transform:translateY(-3px);box-shadow:0 10px 25px #07335a12}.pipeline-card-top{display:flex;justify-content:space-between;align-items:center;font-size:14px}.pipeline-card h2{font-size:29px;margin:20px 0 8px}.pipeline-card h3{font-size:17px;margin:22px 0 10px}.pipeline-card p{font-size:15px}.mechanism{display:inline-block;background:#e4f3f2;color:#005d64;padding:7px 12px;margin-top:17px;border-radius:4px;font-size:14px}.pipeline-source{border-top:1px solid var(--line);margin-top:25px;padding-top:18px;display:flex;flex-wrap:wrap;gap:14px;font-size:14px}.pipeline-source span{width:100%;color:var(--muted)}.pipeline-source a{border-bottom:1px solid #adc7cf}.saved-remove{margin:12px 0 25px}.email-result{overflow-wrap:anywhere}#speaking{scroll-margin-top:25px}
@media(max-width:850px){.tool-nav{grid-template-columns:repeat(2,1fr)}.tool-layout{grid-template-columns:1fr}.tool-inputs{border-right:0;border-bottom:1px solid var(--line)}.pipeline-grid{grid-template-columns:1fr}.tool-result{padding:25px}.tool-panel-heading{padding:25px}.tool-stat strong{font-size:36px}}
@media(max-width:500px){.tool-nav{gap:8px}.tool-nav a{padding:14px}.tool-nav strong{font-size:15px}.tool-nav span{font-size:13px}.tool-inputs{padding:22px}.tool-result{padding:22px}.tool-method{padding:22px}.stat-grid{gap:14px}.tool-stat strong{font-size:30px}.pipeline-card{padding:23px}.tool-panel-heading h2{font-size:29px}.pipeline-summary{gap:15px}}
@media print{header,footer,.preview-note,.skip,.tool-nav,.tool-inputs,.clinical-tools>.page-head,.clinical-tools>.about-links,.print-tool,.print-browser,.print-status{display:none!important}.container{max-width:none;padding:0}.tool-panel{border:0;box-shadow:none}.tool-layout{display:block}.tool-panel-heading{padding:10px 0;background:none}.tool-result{padding:15px 0}.tool-method{padding:12px 0}.tool-result,.tool-panel{overflow:visible}.tool-stat strong{font-size:30px}.clinical-note{break-inside:avoid}.half-chart{max-height:260px}.tool-method a:after{content:' (' attr(href) ')';font-size:10px}.tool-result p a:after{content:' (' attr(href) ')';font-size:10px}body{font-size:12px}p{color:#333}.tool-result p{font-size:12px}*{-webkit-print-color-adjust:exact;print-color-adjust:exact}}

.trial-overview{margin:25px 0}.trial-overview summary{cursor:pointer;font-weight:600;font-size:15px}.trial-row{display:flex;position:relative;width:100%;justify-content:space-between;gap:15px;background:#f4f8fa;border:0;border-radius:6px;text-align:left;padding:17px 15px 22px;margin:12px 0;overflow:hidden;cursor:pointer;color:var(--ink)}.trial-row:hover{background:#e5f1f3}.trial-row span{position:relative;z-index:1}.trial-row small{display:block;font-size:12px;margin-top:5px}.trial-row strong{font-size:15px}.trial-row i{position:absolute;height:5px;bottom:0;left:0;background:var(--teal)}@media print{.trial-overview{display:none!important}}

.ruler-labels{position:relative;height:20px;display:block}.ruler-labels span{position:absolute;transform:translateX(-50%)}.ruler-labels span:first-child{transform:none}.ruler-labels span:last-child{transform:translateX(-100%)}.tool-inputs:has(#trial) .input-grid>label{grid-column:1/-1}
.mechanism-group{margin:44px 0}.group-heading{display:flex;align-items:baseline;justify-content:space-between;gap:20px;border-bottom:1px solid #d7e3e8;margin-bottom:22px;padding-bottom:14px}.group-heading h2{margin:0}.group-heading>span{color:#62778a;font-size:13px}.drug-name{font-size:25px!important;margin:16px 0 4px!important}.phase-steps{display:flex;gap:6px;margin:20px 0}.phase-steps span{flex:1;border-top:4px solid #e3eaef;padding-top:5px;font-size:11px;color:#63798c}.phase-steps .reached{border-color:#009fa4;color:#004e68}.half-scrub{display:block;font-size:13px}.half-scrub input{width:100%;accent-color:#00757c}#half-readout{display:block;font-variant-numeric:tabular-nums}.hormone-tabs{display:flex;gap:10px;margin:20px 0 32px;flex-wrap:wrap}.hormone-tabs button,.organ-choices button{border:1px solid #cadce3;border-radius:30px;padding:12px 25px;background:white;color:#003660;font:inherit;cursor:pointer}.hormone-tabs button[aria-pressed=true],.organ-choices button[aria-pressed=true]{background:#003660;color:white;border-color:#003660}.anatomy-layout{display:grid;grid-template-columns:1fr 1fr;gap:55px;align-items:start}.anatomy-figure{position:relative;max-width:520px}.anatomy-figure img{width:100%;height:auto;display:block}.anatomy-figure>p{font-size:12px;color:#607487}.organ-point{position:absolute;width:24px;height:24px;border:3px solid white;background:#00a6aa;border-radius:50%;box-shadow:0 0 0 6px #00a6aa30;transform:translate(-50%,-50%);cursor:pointer}.organ-point[aria-pressed=true]{background:#003660;box-shadow:0 0 0 9px #00366025}.organ-point span{position:absolute;left:24px;top:-6px;padding:4px 8px;background:#ffffffee;color:#003660;border-radius:5px;font-size:11px;white-space:nowrap}.anatomy-info{position:sticky;top:110px;padding-top:22px}.anatomy-info h2{font-size:27px;line-height:1.3}.organ-choices{display:flex;gap:8px;flex-wrap:wrap;margin:24px 0}.organ-choices button{font-size:13px;padding:8px 13px}.organ-detail{padding:28px;background:#f0f7f8;border:1px solid #d4e6e9;border-radius:18px;min-height:250px;margin-bottom:24px}.organ-detail h3{font-size:23px;margin:20px 0 14px}.indications{margin-top:65px}.indications h4{margin-bottom:8px}.indications h3{font-size:32px}.half-chart{touch-action:pan-y}button:focus-visible,input:focus-visible{outline:3px solid #e8ac4e;outline-offset:3px}@media(max-width:750px){.anatomy-layout{grid-template-columns:1fr;gap:20px}.anatomy-figure{max-width:380px;margin:auto}.anatomy-info{position:static}.anatomy-info h2{font-size:24px}.group-heading{align-items:start;flex-direction:column;gap:8px}.hormone-tabs button{padding:10px 17px}.organ-point span{font-size:10px;left:19px}}@media print{.hormone-tabs,.organ-choices{display:none}.anatomy-info{position:static}}
#organ-points{position:absolute;inset:0 0 auto;aspect-ratio:1086/1448;pointer-events:none}#organ-points button{pointer-events:auto}
.tool-inputs .input-grid>label[hidden]{display:none!important}

.fib4-context{margin:28px 0 0;padding:clamp(22px,4vw,40px);background:#f3f8f9;border:1px solid var(--line);border-radius:14px}
.fib4-context-intro{max-width:820px;margin:0 0 24px}
.fib4-context-intro h2{font-size:30px;line-height:1.2;margin:8px 0 10px}
.fib4-context-intro p,.fib4-definition p,.fib4-next p{font-size:16px;line-height:1.65}
.fib4-context-grid{display:grid;grid-template-columns:minmax(240px,.75fr) minmax(0,1.25fr);gap:24px;align-items:start}
.fib4-feature-visual{display:block;max-width:480px;margin:0 auto;color:var(--ink);background:#fff;border:1px solid var(--line);border-radius:10px;overflow:hidden;text-decoration:none;box-shadow:0 7px 22px #07335a0b}
.fib4-feature-visual img{display:block;width:100%;height:auto}
.fib4-feature-visual>span{display:block;padding:14px 16px;color:var(--teal);font-size:15px;font-weight:600}
.fib4-feature-visual:hover>span{text-decoration:underline}
.fib4-spectra{display:grid;gap:14px}
.fib4-definition{padding:21px;background:#fff;border:1px solid var(--line);border-radius:10px}
.fib4-label{display:block;margin-bottom:9px;color:var(--teal);font-size:13px;font-weight:700;letter-spacing:.08em}
.fib4-definition h3{font-size:21px;line-height:1.3;margin:0 0 9px}
.fib4-definition p{margin:10px 0 0}
.fib4-stage-scale{display:grid;grid-template-columns:repeat(5,minmax(0,1fr));gap:6px;padding:0;margin:16px 0 8px;list-style:none}
.fib4-stage-scale li{min-width:0;padding:10px 5px;text-align:center;background:#f1f6f8;border-top:4px solid #9cbecb;border-radius:4px}
.fib4-stage-scale li:nth-child(2){background:#eaf4f5;border-color:#72aeb6}
.fib4-stage-scale li:nth-child(3){background:#e0f1ee;border-color:#29999a}
.fib4-stage-scale li:nth-child(4){background:#d3e9e8;border-color:#187a86}
.fib4-stage-scale li:nth-child(5){background:#d7e1ef;border-color:#234d75}
.fib4-stage-scale strong,.fib4-stage-scale span{display:block}
.fib4-stage-scale strong{font:600 18px/1.2 Manrope;color:var(--ink)}
.fib4-stage-scale span{margin-top:4px;font-size:13px;line-height:1.25;color:var(--muted)}
.fib4-next{margin-top:24px;padding:25px;background:#fff;border:1px solid var(--line);border-radius:12px}
.fib4-next-heading{max-width:790px}
.fib4-next-heading h3{font-size:23px;margin:8px 0}
.fib4-pathway{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px;margin-top:18px}
.fib4-pathway article{padding:19px;background:#f6f9fa;border-radius:8px;border:1px solid #e0eaee}
.fib4-pathway article>span{color:var(--teal);font-size:13px;font-weight:700;letter-spacing:.06em}
.fib4-pathway h4{font-size:18px;line-height:1.35;margin:8px 0}
.fib4-pathway p{margin:0}
.fib4-thresholds{margin:17px 0 0;padding:14px 16px;background:#eef5f8;border-left:3px solid #258b98;border-radius:0 6px 6px 0}
.fib4-sources{margin:18px 0 0;font-size:14px;line-height:1.7;color:var(--muted)}
.fib4-sources a{color:var(--teal);text-decoration:underline}
@media(max-width:800px){.fib4-context-grid{grid-template-columns:1fr}.fib4-feature-visual{width:min(100%,470px)}.fib4-pathway{grid-template-columns:1fr}}
@media(max-width:520px){.fib4-context{padding:22px 16px}.fib4-context-intro h2{font-size:26px}.fib4-definition,.fib4-next{padding:18px}.fib4-stage-scale{gap:4px}.fib4-stage-scale li{padding:8px 3px}.fib4-stage-scale span{font-size:12px}}
@media print{.fib4-context{display:none!important}}

/* Therapy atlas: compact, visual overview and reusable drug profiles. */
.atlas,.atlas-profile{padding-bottom:68px}.atlas-intro{display:flex;align-items:end;justify-content:space-between;gap:30px;padding:50px 0 32px}.atlas-intro h1{font-size:clamp(40px,5vw,66px);line-height:1.06;margin:12px 0 18px}.atlas-intro p{max-width:740px;font-size:18px;line-height:1.6;margin:0}.atlas-count{min-width:180px;display:flex;align-items:center;gap:12px;border-left:3px solid #13a6a6;padding:7px 0 7px 17px}.atlas-count strong{font:700 48px/1 Manrope,sans-serif;color:#00536c}.atlas-count span{font-size:13px;line-height:1.45;color:#526b7a}.atlas-map{border:1px solid #d3e4e8;border-radius:17px;padding:clamp(22px,3vw,34px);background:linear-gradient(125deg,#eef8f7,#f6fafb 60%,#eaf2f8)}.atlas-map-heading{display:flex;align-items:end;justify-content:space-between;gap:16px}.atlas-map h2{margin:5px 0 22px;font-size:28px}.atlas-map-heading a{font-weight:600;color:#00787d;text-decoration:underline;text-underline-offset:3px}.atlas-map-grid{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:10px}.atlas-path{position:relative;background:#fff;border:1px solid #d9e8ec;border-radius:11px;padding:20px 14px;display:flex;align-items:center;gap:12px;min-width:0}.atlas-path-num{position:absolute;right:11px;top:8px;font-size:11px;color:#839baa}.atlas-path-symbol{display:grid;place-items:center;flex:none;width:50px;height:50px;border-radius:14px;background:#dceff0;color:#006777;font:700 13px Manrope,sans-serif;letter-spacing:-.04em}.atlas-path-symbol.target-gip{background:#e1e9f5;color:#345c86}.atlas-path-symbol.target-glucagon{background:#e7edf1;color:#415b70}.atlas-path-symbol.target-amylin{background:#d8f1e9;color:#08766c}.atlas-path strong,.atlas-path small{display:block}.atlas-path strong{font-size:16px}.atlas-path small{font-size:12px;line-height:1.35;color:#60788a;margin-top:4px}.atlas-map>p{font-size:13px;color:#617788;margin:19px 0 0}.atlas-browse{margin-top:49px}.atlas-browse-title{display:flex;justify-content:space-between;align-items:baseline;gap:20px}.atlas-browse-title h2{font-size:32px;margin:0 0 20px}.atlas-browse-title p{color:#607588;font-size:14px;margin:0}.atlas-filters{display:grid;grid-template-columns:2fr 1fr 1fr;gap:12px}.atlas-filters input,.atlas-filters select{width:100%;min-width:0;padding:13px 14px;border:1px solid #bdced5;border-radius:8px;background:#fff;color:var(--ink);font:inherit;font-size:15px}.atlas-chips{display:flex;gap:8px;overflow-x:auto;padding:16px 0 5px;scrollbar-width:thin}.atlas-chips button{white-space:nowrap;background:#f5f9fa;color:#294b5d;border:1px solid #d8e5e9;border-radius:40px;padding:9px 15px;font:600 13px Manrope,sans-serif;cursor:pointer}.atlas-chips button[aria-pressed=true]{background:#003c60;border-color:#003c60;color:#fff}.atlas-browse .results-count{font-size:13px;color:#657c8a;margin:18px 0 4px}.atlas-group{margin:24px 0 42px}.atlas-group-head{display:flex;align-items:center;justify-content:space-between;padding-bottom:12px;border-bottom:1px solid #d8e4e8;margin-bottom:16px}.atlas-group-head h2{font-size:25px;margin:0}.atlas-group-head span{font-size:14px;color:#68808d}.atlas-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:15px}.atlas-card{min-width:0;display:flex;flex-direction:column;border:1px solid #d7e4e8;border-radius:13px;background:#fff;overflow:hidden;box-shadow:0 7px 25px #06335309;transition:transform .2s,box-shadow .2s}.atlas-card:hover{transform:translateY(-3px);box-shadow:0 15px 35px #06335318}.atlas-card-top{display:flex;align-items:center;justify-content:space-between;gap:10px;padding:18px 20px 0;font-size:12px}.atlas-stage{font-weight:700;background:#dff3f0;color:#006973;padding:6px 10px;border-radius:5px}.atlas-route{color:#526e7e}.atlas-card-title{display:flex;gap:10px;align-items:baseline;justify-content:space-between;margin:17px 20px 0;color:var(--ink)}.atlas-card-title h3{font-size:22px;line-height:1.25;margin:0;overflow-wrap:anywhere}.atlas-card-title>span{color:#008a8c}.atlas-card-title:hover h3{text-decoration:underline;text-decoration-color:#37b4b0;text-underline-offset:3px}.atlas-sponsor{font-size:13px;color:#697c89;margin:6px 20px 15px}.atlas-targets{display:flex;gap:5px;flex-wrap:wrap;margin:0 20px 13px}.atlas-target{font:700 11px Manrope,sans-serif;border-radius:4px;padding:5px 7px;background:#e1f2f2;color:#006677}.atlas-target.target-gip{background:#e4eefa;color:#315d85}.atlas-target.target-glucagon{background:#e9eff3;color:#3f5c71}.atlas-target.target-amylin{background:#dff3eb;color:#087669}.atlas-target.target-adjunct{background:#f1eafa;color:#72568c}.atlas-steps{display:flex;gap:4px;margin:0 20px 13px}.atlas-steps span{flex:1;border-top:4px solid #e3ebee;color:#8a9ba5;padding-top:5px;font-size:11px}.atlas-steps span.done{border-color:#16a8a5;color:#005d70;font-weight:700}.atlas-steps span.filed{border-color:#0b5475}.atlas-card .atlas-blurb{font-size:14px;line-height:1.5;margin:0 20px 16px;color:#24495d}.atlas-card-bottom{border-top:1px solid #e1e9ed;margin:auto 20px 0;padding:15px 0;display:flex;gap:10px;align-items:center;justify-content:space-between}.atlas-card-bottom>span{font-size:13px;line-height:1.45;color:#506979}.atlas-card-bottom b{display:block;color:#1a4658;margin-bottom:3px}.atlas-related{flex:none;width:59px;text-align:center;color:#006d79;font-size:10px;line-height:1.2}.atlas-related img{height:62px;width:51px;object-fit:cover;object-position:top;border:1px solid #cfdee3;border-radius:3px}.atlas-related span{display:block;margin-top:3px}.atlas-read{display:flex;justify-content:space-between;background:#eff7f8;border-top:1px solid #dfeaec;color:#005e71;padding:12px 20px;font-size:13px;font-weight:700}.atlas-read:hover{background:#dff1f1}.atlas-caveat{border-left:3px solid #3299a1;padding:8px 18px;margin:40px 0;color:#526d7e;font-size:14px;line-height:1.65}
.atlas-profile-top{padding:40px 0 0}.atlas-profile-top>a{display:inline-block;margin-bottom:22px}.atlas-profile-hero{display:grid;grid-template-columns:minmax(0,1fr) 225px;gap:30px;align-items:center;padding:35px;background:linear-gradient(130deg,#eaf5f6,#f8fafb);border:1px solid #d8e7e9;border-radius:16px}.atlas-profile-hero h1{font-size:clamp(34px,5vw,58px);line-height:1.1;margin:12px 0}.atlas-aliases{font-size:14px;color:#587082}.atlas-lead{font-size:18px;line-height:1.5;max-width:700px}.atlas-profile-hero .atlas-targets{margin:24px 0 0}.atlas-profile-stage{background:#fff;border-radius:10px;border:1px solid #dce8eb;padding:22px}.atlas-profile-stage>span,.atlas-profile-stage>small{display:block;color:#617887;font-size:13px}.atlas-profile-stage>strong{font:700 29px Manrope,sans-serif;line-height:1.2;display:block;margin:8px 0 22px;color:#00687a}.atlas-profile-stage .atlas-steps{margin:0 0 16px}.atlas-facts{display:grid;grid-template-columns:repeat(4,1fr);gap:1px;background:#dce7eb;border:1px solid #dce7eb;border-radius:10px;overflow:hidden;margin:16px 0 36px}.atlas-facts>div{background:#fff;padding:16px 20px}.atlas-facts span,.atlas-facts strong{display:block}.atlas-facts span{font-size:12px;color:#69808c;margin-bottom:7px}.atlas-facts strong{font-size:14px;line-height:1.4}.atlas-profile-layout{display:grid;grid-template-columns:minmax(0,1.75fr) minmax(260px,.8fr);gap:25px;align-items:start}.atlas-profile-main,.atlas-profile-side{display:grid;gap:22px}.atlas-panel{border:1px solid #d9e5e9;border-radius:12px;padding:clamp(22px,3vw,32px);background:#fff}.atlas-panel h2{font-size:26px;margin:8px 0 21px}.atlas-panel h3{font-size:17px}.atlas-panel p,.atlas-panel li{font-size:15px;line-height:1.65}.atlas-mechanism-map{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:8px;margin:0 0 20px}.atlas-mechanism-map>div{background:#f4f7f9;border:1px solid #e3eaed;border-radius:9px;padding:14px 8px;opacity:.48;text-align:center}.atlas-mechanism-map>div.lit{background:#e9f6f6;border-color:#a8d5d5;opacity:1}.atlas-mechanism-map .atlas-path-symbol{margin:0 auto 9px}.atlas-mechanism-map strong,.atlas-mechanism-map small{display:block}.atlas-mechanism-map strong{font-size:13px}.atlas-mechanism-map small{font-size:11px;color:#657a87}.atlas-formulations{display:grid;gap:9px}.atlas-formulations article{display:flex;justify-content:space-between;gap:20px;background:#f3f8f9;border:1px solid #e0ecee;border-radius:8px;padding:16px}.atlas-formulations article>div:last-child{text-align:right}.atlas-formulations strong,.atlas-formulations span,.atlas-formulations b{display:block;font-size:14px}.atlas-formulations span{margin-top:5px;color:#617888;font-size:13px}.atlas-formulations b{color:#00767a}.atlas-timeline{margin-top:20px;border-left:3px solid #14a4a4;padding:5px 0 5px 20px}.atlas-timeline p{margin:7px 0}.atlas-trials article{display:grid;grid-template-columns:80px 1fr;gap:20px;border-top:1px solid #e1e9ed;padding:18px 0}.atlas-trials article>span{color:#007277;font-size:13px;font-weight:700}.atlas-trials h3{margin:0 0 5px}.atlas-trials p{margin:0 0 5px}.atlas-trials a,.atlas-sources a,.atlas-evidence-context a{color:#006f7b;text-decoration:underline;text-underline-offset:2px}.atlas-evidence{background:#f1f8f8;border:1px solid #d4e8e9;border-radius:10px;padding:22px}.atlas-evidence h3{margin:5px 0}.atlas-evidence-title p{margin:0;color:#657989}.atlas-bars{display:grid;gap:18px;margin:28px 0}.atlas-bars>div{display:grid;grid-template-columns:minmax(90px,135px) minmax(0,1fr) 70px;gap:12px;align-items:center;font-size:13px}.atlas-bars>div>div{background:#dce7eb;height:18px;border-radius:4px;overflow:hidden}.atlas-bars i{display:block;height:100%;background:#007b82;border-radius:4px}.atlas-bars>div:nth-child(2) i{background:#8baeb9}.atlas-bars strong{text-align:right}.atlas-evidence-context{font-size:13px!important;color:#536b7b}.atlas-evidence-disclaimer{font-size:13px!important;color:#617788}.atlas-no-data{background:#f3f8f9;border:1px dashed #bbd2d9;border-radius:9px;padding:24px}.atlas-no-data p{margin-bottom:0}.atlas-sources{padding:0;list-style:none}.atlas-sources li{border-bottom:1px solid #e2eaed;padding:12px 0}.atlas-sources span{display:block;color:#667e89;font-size:12px}.atlas-profile-side .source-note,.atlas-profile-side small{font-size:12px;color:#657d89;line-height:1.6}.atlas-profile-visual a{display:block}.atlas-profile-visual img{width:100%;height:auto;max-height:350px;object-fit:contain;object-position:top;background:#f4f7f8}.atlas-profile-visual a span{display:block;margin-top:12px;color:#00737a;font-size:14px;font-weight:700}.atlas-profile-back{margin-top:30px}
@media(max-width:1050px){.atlas-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.atlas-map-grid{grid-template-columns:repeat(2,minmax(0,1fr))}}
@media(max-width:750px){.atlas-intro{align-items:start;flex-direction:column;padding:36px 0 25px}.atlas-count{min-width:0}.atlas-browse-title{display:block}.atlas-browse-title p{margin-bottom:14px}.atlas-filters{grid-template-columns:1fr 1fr}.atlas-filters input{grid-column:1/-1}.atlas-profile-hero{grid-template-columns:1fr;padding:24px}.atlas-profile-stage{max-width:300px}.atlas-profile-layout{grid-template-columns:1fr}.atlas-facts{grid-template-columns:repeat(2,1fr)}}
@media(max-width:570px){.atlas-grid,.atlas-map-grid{grid-template-columns:1fr}.atlas-map-heading{display:block}.atlas-map-heading a{display:inline-block;margin-bottom:16px}.atlas-path{padding:13px}.atlas-card-title h3{font-size:21px}.atlas-filters{grid-template-columns:1fr 1fr}.atlas-browse-title h2{font-size:28px}.atlas-mechanism-map{grid-template-columns:repeat(2,1fr)}.atlas-bars>div{grid-template-columns:1fr 65px;gap:8px}.atlas-bars>div>span{grid-column:1/-1}.atlas-trials article{grid-template-columns:1fr;gap:3px}.atlas-formulations article{gap:12px}.atlas-facts>div{padding:14px}}
@media(prefers-reduced-motion:reduce){.atlas-card{transition:none}.atlas-card:hover{transform:none}}

.atlas-group-adjunct{padding:25px;border:1px solid #e1dbec;background:#fbf9fd;border-radius:15px}.atlas-group-adjunct .atlas-group-head{border-color:#ded6ea}.atlas-visual-date{font-size:12px!important;color:#637988;margin:12px 0 0}
@media(max-width:570px){.atlas-group-adjunct{padding:16px}}

/* Clinical tool interaction and printable summary */
.tool-print-header{display:none}.print-help{font-size:12px!important;color:var(--muted);margin-top:8px!important}.tool-panel-heading h2:focus{outline:none}.half-chart-wrap{position:relative;margin:20px 0}.half-chart-wrap .half-chart{margin:0}.half-tooltip{position:absolute;left:clamp(86px,var(--tip-x),calc(100% - 86px));transform:translate(-50%,-115%);min-width:172px;padding:9px 12px;background:#003660;color:#fff;border-radius:8px;box-shadow:0 8px 22px #00366038;pointer-events:none;white-space:nowrap;font-size:12px;line-height:1.35;z-index:2}.half-tooltip[hidden]{display:none}.half-tooltip strong,.half-tooltip span{display:block}.half-tooltip span{opacity:.88;margin-top:2px}@media(max-width:500px){.half-tooltip{font-size:11px;min-width:150px;left:clamp(75px,var(--tip-x),calc(100% - 75px))}}
@media print{.tool-print-header{display:flex;align-items:center;gap:22px;padding:0 0 15px;border-bottom:2px solid #00757c;margin-bottom:15px}.tool-print-header img{width:175px;height:auto;object-fit:contain}.tool-print-header div{display:grid;gap:4px;font-size:13px}.tool-print-header span{font-size:10px;color:#526a78}.print-help,.half-tooltip{display:none!important}.tool-print-header,.tool-panel-heading,.tool-result,.tool-method{break-inside:avoid}}
/* Pipeline atlas refinements */
.atlas-card{padding-bottom:0}
.atlas-card .atlas-blurb{font-size:14px;line-height:1.45;margin-bottom:14px;min-height:2.9em}
.atlas-card-snapshot{margin:auto 18px 14px;padding:12px 13px;background:linear-gradient(120deg,#eef7f7,#f6fafb);border:1px solid #dce9ea;border-radius:8px}
.atlas-card-snapshot span,.atlas-card-snapshot strong,.atlas-card-snapshot small{display:block}
.atlas-card-snapshot span{font-size:10px;line-height:1.35;color:#617984;text-transform:uppercase;letter-spacing:.04em}
.atlas-card-snapshot strong{font-size:15px;line-height:1.35;color:#004e68;margin-top:5px;font-variant-numeric:tabular-nums}
.atlas-card-snapshot small{font-size:11px;color:#607789;margin-top:3px}
.atlas-focus-chips{display:flex;flex-wrap:wrap;gap:6px;margin:16px 0 0}
.atlas-focus-chips span{font-size:12px;line-height:1.25;padding:6px 9px;border-radius:20px;color:#285b66;background:#fff;border:1px solid #cbdfe2}
.atlas-completed{margin:22px 0 0;border:1px solid #ded7e9;background:#fcfaff;border-radius:12px;overflow:hidden}
.atlas-completed>details>summary{display:flex;justify-content:space-between;gap:15px;align-items:center;cursor:pointer;padding:17px 20px;color:#3d3450;font-weight:700;list-style:none}
.atlas-completed>details>summary::-webkit-details-marker{display:none}
.atlas-completed>details>summary:after{content:"+";font-size:21px;color:#765c89}
.atlas-completed>details[open]>summary:after{content:"−"}
.atlas-completed>details>summary span{margin-left:auto;color:#786e84;font-size:12px;font-weight:500}
.atlas-completed-card{display:flex;align-items:center;justify-content:space-between;gap:24px;padding:20px;border-top:1px solid #e8e2ee;background:white}
.atlas-completed-card h3{font-size:19px;margin:6px 0}
.atlas-completed-card p{max-width:760px;margin:0;color:#536a78;font-size:14px;line-height:1.5}
.atlas-completed-card .text-link{white-space:nowrap}
.atlas-safety{background:#fffaf3;border-color:#eee0c9}
.atlas-safety h2{margin-bottom:8px}
.atlas-safety p{margin:0}
.atlas-steps span{font-size:10px}
@media(max-width:570px){.atlas-completed>details>summary{align-items:flex-start;flex-direction:column;gap:4px}.atlas-completed>details>summary span{margin-left:0}.atlas-completed-card{align-items:flex-start;flex-direction:column;gap:12px}.atlas-card-snapshot{margin-left:14px;margin-right:14px}}
.atlas-card .atlas-read{margin-top:auto}