47 pipeline profiles195 study records tracked Updated November 9, 2026
01 GLP-1 GLP-1 Satiety and glucose signaling
02 GIP GIP Incretin signaling studied alone or with GLP-1
03 GCG glucagon Energy and liver signaling
04 AMY amylin Meal-related fullness
05 OTH Other targets Body composition and other targets
Choose a target to filter programs. Combinations may appear under more than one pathway; body composition and other targets are grouped separately.
Explore the programs Obesity phase is shown by formulation and region where they differ.
All stages Phase 3 and filed Phase 2 All routes Oral Injection Infusion All study foci
47 of 47 pipeline profiles
Stages refer to obesity development, with formulation and regional context. Column spacing does not represent time to approval.
Amylin & combinations14 programs Phase 2 ABBV-295 Quick view ↗ Long-acting amylin analogue · Injection · Study regimen Initiated August 2026; results pending Investigational long-acting amylin analogue in a Phase 2 dose-finding study. amylin
Full profile ↗ Amylin 355 (NN9638) Quick view ↗ Oral tablet Initiated per sponsor An amylin program with separate oral and subcutaneous development. amylin
Full profile ↗ Amylin 355 (NN9638) Quick view ↗ Injection Initiated per sponsor An amylin program with separate oral and subcutaneous development. amylin
Full profile ↗ AZD9550 + lenbelintide Quick view ↗ Injection · Once weekly Initiated Amylin plus GLP-1/glucagon co-administration; its own Phase 2 program. GLP-1 glucagon amylin
Full profile ↗ Berobenatide + MET233i Quick view ↗ Injection · Once weekly Initiated Long-acting GLP-1 plus amylin/calcitonin activity. GLP-1 amylin
Full profile ↗ MET233i Quick view ↗ Injection · Once weekly Initiated Long-acting amylin analogue with dual amylin/calcitonin activity. amylin
Full profile ↗ NN9662 (Triple) Quick view ↗ Injection · Once weekly Phase 2 obesity development listed A triple agonist pairing GLP-1 and GIP signaling with amylin rather than glucagon. GLP-1 GIP amylin
Full profile ↗ Petrelintide + enicepatide Quick view ↗ Co-administered injection · Injection · Once weekly Phase 2 trial registered; initiation planned H2 2026 Amylin plus GIP/GLP-1 combination tested against components. amylin GLP-1 GIP
Full profile ↗ Phase 3 Cagrilintide Quick view ↗ Injection · Once weekly RENEW 1 initiated Standalone amylin analogue, distinct from its CagriSema combination. amylin
Full profile ↗ Eloralintide Quick view ↗ Injection · Once weekly Initiated Selective amylin agonist tested as monotherapy and adjunctive treatment. amylin
Full profile ↗ EloraTZP Quick view ↗ Eloralintide + tirzepatide · Injection · Once weekly AMPLIFY-2 recruiting; AMPLIFY-1 registered, not yet recruiting Eloralintide is added to tirzepatide as a distinct obesity strategy. amylin GLP-1 GIP
Full profile ↗ Lenbelintide Quick view ↗ Injection · Once weekly SELENE trials registered Selective amylin receptor agonist, including an adjunctive Phase 3 strategy. amylin
Full profile ↗ Petrelintide Quick view ↗ Injection · Once weekly ZUPREME initiated Long-acting amylin analogue studied alone and as a combination partner. amylin
Full profile ↗ Zenagamtide Quick view ↗ Injection · Once weekly AMAZE initiated One molecule activates both GLP-1 and amylin receptors. GLP-1 amylin
Full profile ↗ Zenagamtide Quick view ↗ Tablet · Oral tablet · Once daily AMAZE program initiated One molecule activates both GLP-1 and amylin receptors. GLP-1 amylin
Full profile ↗ Filed for review CagriSema Quick view ↗ Fixed-dose injection · Injection · Once weekly Application submitted Two molecules in one injection: amylin analogue plus semaglutide. GLP-1 amylin
Full profile ↗ GLP-1 / GIP10 programs Phase 2 ALV-100 Quick view ↗ Injection PRESERVE recruiting A fusion protein combining GLP-1 receptor agonism with GIP receptor antagonism. GLP-1 GIP
Full profile ↗ BI 3034701 Quick view ↗ Injection Phase 2 dose-finding study initiated July 2026 An investigational triple receptor agonist targeting GLP-1, GIP and NPY2 receptors. GLP-1 GIP NPY2
Full profile ↗ Oral ribupatide Quick view ↗ Tablet · Oral tablet · Once daily China Phase 2 result reported; global Phase 3 planned for H1 2027, not initiated Daily oral formulation has Phase 2 obesity data; global Phase 3 is planned for H1 2027. GLP-1 GIP
Full profile ↗ Phase 3 Enicepatide Quick view ↗ Injection · Once weekly Initiated Once-weekly GLP-1/GIP dual agonist in Phase 3 weight-management trials. GLP-1 GIP
Full profile ↗ MariTide Quick view ↗ Injection · Monthly; less-frequent schedules under study Initiated GLP-1 agonism with GIP receptor antagonism and less-frequent dosing under study. GLP-1 GIP
Full profile ↗ Olatorepatide Quick view ↗ Injection · Once weekly China trial completed; global Phase 3 planned Dual-biased GLP-1/GIP agonist with Phase 3 LIGHTEN primary results presented at EASD 2026; global development and regulatory outcomes remain ahead. GLP-1 GIP
Full profile ↗ Poterepatide (HDM1005) Quick view ↗ Injection · China · Injection China obesity Phase 3 enrollment complete; follow-up/data collection ongoing Long-acting injectable GLP-1/GIP dual agonist in China Phase 3 obesity development. U.S. obesity development has not been confirmed. GLP-1 GIP
Full profile ↗ Ribupatide injection Quick view ↗ Injection · Once weekly Global KaiNETIC Phase 3 active; China Phase 3 results reported Global Phase 3 is underway; U.S. high-dose Phase 2b results are expected in mid-2027. GLP-1 GIP
Full profile ↗ VK2735 injection Quick view ↗ Injection · Once weekly VANQUISH Phase 3 active Weekly injectable dual GIP/GLP-1 agonist in global pivotal obesity trials. GLP-1 GIP
Full profile ↗ VK2735 oral Quick view ↗ Tablet · Oral tablet · Once daily SUNRISE Phase 3 program initiated October 14, 2026 Once-daily oral GLP-1/GIP agonist; the Phase 3 SUNRISE program began in October 2026. GLP-1 GIP
Full profile ↗ Filed for review No selected programs
GIP-focused1 programs Phase 2 Macupatide Quick view ↗ Injection · Once weekly Phase 2 obesity studies include participants with and without type 2 diabetes A long-acting GIP receptor agonist studied alone and with eloralintide. GIP
Full profile ↗ Phase 3 No selected programs
Filed for review No selected programs
Glucagon-containing6 programs Phase 2 HM15275 Quick view ↗ Injection · Once weekly U.S. obesity Phase 2 active Weekly GLP-1/GIP/glucagon tri-agonist; Phase 2 is testing weight change and lean-mass outcomes. GLP-1 GIP glucagon
Full profile ↗ LY4086940 Quick view ↗ Oral peptide · Oral tablet · Study regimen Registered; not yet recruiting; estimated start November 2026 Investigational oral GLP-1/GIP/glucagon triple agonist peptide with a newly registered Phase 2 obesity study. GLP-1 GIP glucagon
Full profile ↗ Pemvidutide Quick view ↗ Injection · Once weekly MOMENTUM obesity study completed GLP-1/glucagon agonist; current Phase 3 work centers on MASH. GLP-1 glucagon
Full profile ↗ UBT251 Quick view ↗ Injection · Once weekly China Phase 2 complete; global 1b/2a ongoing Triple agonist with obesity Phase 2 evidence in China. GLP-1 GIP glucagon
Full profile ↗ Phase 3 Retatrutide Quick view ↗ Injection · Once weekly Initiated A once-weekly triple agonist targeting GLP-1, GIP and glucagon. GLP-1 GIP glucagon
Full profile ↗ Survodutide Quick view ↗ Injection · Once weekly Initiated Glucagon/GLP-1 dual agonist studied in obesity, type 2 diabetes, and liver disease. GLP-1 glucagon
Full profile ↗ Filed for review No selected programs
GLP-1 focused11 programs Phase 2 ASC30 Quick view ↗ Depot injection · Injection · Monthly treatment; quarterly maintenance under study Phase 2 depot-efficacy results reported; next development stage not confirmed. One small molecule explored as an oral tablet and long-acting depot. GLP-1
Full profile ↗ VCT220 / CX11 Quick view ↗ CX11 · U.S./global · Oral tablet U.S. Phase 2 topline reported; global Phase 3 planned, not initiated The same oral small-molecule GLP-1 medicine is called VCT220 in China and CX11 outside Greater China; obesity studies are at different stages by region. GLP-1
Full profile ↗ CT-996 Quick view ↗ Tablet · Oral tablet · Once daily Phase 2 obesity study completed; results pending Oral small-molecule GLP-1 agonist in obesity Phase 2. GLP-1
Full profile ↗ Naperiglipron Quick view ↗ Oral small molecule · Oral tablet Phase 2; original obesity study completed; separate protocol terminated An oral small-molecule GLP-1 receptor agonist listed in Lilly’s obesity pipeline. GLP-1
Full profile ↗ VRB-101 Quick view ↗ Once-weekly oral peptide · Oral tablet · Once weekly EVOLVE-2 Phase 2b completed; topline expected by year-end 2026 A once-weekly oral formulation of ecnoglutide, a GLP-1 peptide analogue. GLP-1
Full profile ↗ Phase 3 Aleniglipron Quick view ↗ Oral tablet · Once daily Initiated Once-daily oral small-molecule GLP-1 receptor agonist. GLP-1
Full profile ↗ ASC30 Quick view ↗ Tablet · Oral tablet · Once daily Global Phase 3 AURORA-1 and AURORA-2 initiated; 72-week pivotal studies. One small molecule explored as an oral tablet and long-acting depot. GLP-1
Full profile ↗ Berobenatide Quick view ↗ Injection · Once weekly VESPER obesity studies initiated Long-acting injectable GLP-1 agonist testing weekly and monthly schedules. GLP-1
Full profile ↗ Berobenatide Quick view ↗ Injection · Once monthly maintenance VESPER-6 initiated Long-acting injectable GLP-1 agonist testing weekly and monthly schedules. GLP-1
Full profile ↗ Bofanglutide (GZR18) Quick view ↗ Injection · Every two weeks; monthly maintenance studied China Phase 3 induction and Phase 3b monthly maintenance toplines reported GLP-1 injection with biweekly induction studies and a separate monthly maintenance study. GLP-1
Full profile ↗ Conveglipron (HDM1002) Quick view ↗ Oral · China · Oral tablet China Phase 3 primary endpoint met; pre-NDA submitted July 2026; China NDA planned Q4 2026 Oral small-molecule GLP-1 medicine in late-stage obesity development in China. U.S. obesity development has not been confirmed. GLP-1
Full profile ↗ Elecoglipron Quick view ↗ Oral tablet · Once daily Initiated Once-daily oral small-molecule GLP-1 agonist. GLP-1
Full profile ↗ Safiglipron (KAI-7535 / HRS-7535) Quick view ↗ Tablet · Oral tablet · Once daily China Phase 3 reported; global Phase 2 ongoing Daily oral small-molecule GLP-1 agonist; China Phase 3 topline with a separate global Phase 2 underway. GLP-1
Full profile ↗ VCT220 / CX11 Quick view ↗ VCT220 · China · Oral tablet China Phase 3 topline reported; NDA planned near term The same oral small-molecule GLP-1 medicine is called VCT220 in China and CX11 outside Greater China; obesity studies are at different stages by region. GLP-1
Full profile ↗ Filed for review No selected programs
Body composition & other targets5 programs Phase 2 Bimagrumab Quick view ↗ IV antibody · Infusion · Every 12 weeks in studied regimen Trial published Activin type II receptor antibody investigated with incretin therapy. activin II receptor
Full profile ↗ ECC4703 Quick view ↗ ECC4703 + semaglutide · Oral tablet · Daily tablet + weekly injection U.S. MIST Phase 2a; active, not recruiting; results pending Oral THR-β agonist studied as an adjunct to semaglutide for obesity, including effects on weight, liver fat and body composition. THR-β
Full profile ↗ Enobosarm Quick view ↗ Enobosarm + semaglutide · Oral tablet · Daily tablet + weekly injection U.S. PLATEAU study fully enrolled; results pending Oral selective androgen receptor modulator studied with semaglutide for lean-mass preservation and weight reduction in older adults with obesity. Androgen receptor
Full profile ↗ Taldefgrobep alfa Quick view ↗ Injection Phase 2 ongoing; GLP-1 combination amendment planned; topline expected H2 2027 A myostatin/activin-pathway inhibitor being studied for weight reduction and body composition. Myostatin Activin
Full profile ↗ Trevogrumab ± garetosmab + semaglutide Quick view ↗ Antibodies + semaglutide · Injection · Study regimen COURAGE ongoing Myostatin blockade, with or without activin A blockade, alongside semaglutide. myostatin activin A GLP-1
Full profile ↗ Phase 3 No selected programs
Filed for review No selected programs
A curated inventory of major Phase 2, Phase 3 and regulatory-stage obesity programs, plus selected body-composition and other-target medicines. “Planned” does not mean initiated. Study-focus labels identify the condition or outcome a trial evaluates; they do not imply an approved use. A Phase 3 study in MASH or diabetes alone does not upgrade a drug’s obesity stage. Results across trials are not head-to-head comparisons. Approved therapies are covered on the approved-medicines page.